Microbial enzymes are widely utilized as biocatalysts in fields such as biotechnology, agriculture, and pharmaceuticals.
Metagenomic data serve as a valuable resource for identifying novel CUEs from previously unknown microbes present in complex microbial communities across diverse ecosystems.
[1] A curated set of 510 CUEs was developed using publicly available information and categorized into nine broad application areas based on their functional roles.
Through homology-based analysis of ten publicly available metagenomic datasets, several novel CUEs with homology to the curated set were discovered.
MetaBioME provides a resource for uncovering novel homologs of existing CUEs and identifying previously unknown enzymes, which can serve as leads for experimental validation.