Common Terminology Criteria for Adverse Events

The Common Terminology Criteria for Adverse Events (CTCAE),[1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy.

The CTCAE system is a product of the US National Cancer Institute (NCI).

Many clinical trials, now extending beyond oncology, encode their observations based on the CTCAE system.

Grade 2: is moderate; minimal, local or noninvasive intervention was needed.

Grade 3: Severe symptoms or medically significant but not life-threatening but may be disabling or limit self care in ADL Grade 4: is Life threatening consequences; urgent or emergent intervention needed Grade 5: Death related to or due to adverse event[3]