The accompanying music video was directed by Emilio, filmed in Miami, Florida, and features dramatic scenes of Estefan in front of a mirror remembering her former lover.

[6] Musically, "Cómo Me Duele Perderte" is a mid-tempo fusion genre of salsa and bachata that features a Dominican melody and Cuban percussions.

[9] In the lyrics, the singer narrates the pain of losing someone;[7] Estefan dedicated the song to Tito Puente who died a month prior to the single's release.

[11] The accompanying music video was directed by Emilio, filmed in Miami, Florida and is according Lorena Corpus of El Norte "characterized by the transformation achieved by the Cuban singer, as well as scenes loaded with drama".

[15] Billboard critic Michael Paoletta wrote in a favorable review of the remixes that the artist is "ultra-fine form as she gets rhythmically worked over by some of club-lands's finest".