An accompanying music video directed by Emilio was filmed in Miami, Florida, and features Gloria dancing with extras at the Tropicana Club.

[14] The accompanying music video was directed by Emilio Estefan, filmed at the Tropicana Club in Miami, Florida, recorded in 24 hours, and released on March 28, 2000.

[16] At the 2001 Billboard Music Video Awards, the visual was nominated "Best Clip of the Year" under the Latin field but ultimately lost to "She Bangs" by Ricky Martin.

[21] Writing for The Boston Globe, Cindy Rodriguez stated that the artist "really cuts loose" on the "brassy" track and sings "with fiery brilliance".

[3] The San Diego Union-Tribune contributor Ernesto Portillo Jr. complimented "No Me Dejes de Querer" as a "solid salsa dance number".

[25] Elysa Gardner wrote for USA Today: "Those seeking zestier fare can check out the sexy, horns-fueled 'No Me Dejes de Querer'".

[27] The Sunday Mail's Kris Teo commented that the song "smacks with a happy party feel with a breathtaking salsa mid- section".

[1] The Observer's Neil Spencer, who was not impressed with Alma Caribeña, opined that "things only catch fire on the finale, 'No Me Dejes de Querer', where Estefan does battle with some snorting brass".

[30] In an unfavorable review of the album, The Morning Call contributor Len Righi cited "No Me Dejes de Querer" as showing "how little consequence she is" and wrote that Reguiera outperformed her on the remix, which she described as the "most exciting track on the disc".

Costa lambasted the track as an "abysmal song, the kind of spangly, flashing-lights-and-thrusting-rhythm tackiness you hear blaring from the speakers of every crap tourist disco from Benidorm to Barbados; something that parents of teenagers dance to in their exclusive resort hotels.

[39] Furthermore, it reached 100 in the Netherlands,[40] 76 in Switzerland,[41] and numbers 8 and 31 on the Billboard Dance Club Songs and Regional Mexican Airplay charts in the United States, respectively.