Complex lasso proteins

[1][2] Complex lassos can be divided according to the number of piercings through the minimal surface spanned on the covalent loop.

[4][5] In particular, four classes of complex lasso proteins exist: Another classification may be given according to the nature of the bridge closing the covalent loop.

In particular, in case of lasso peptides, the motif allows to act like a plug for specific NTP-uptake channels.

[8][9][10] The motif has also shown significant inhibitory activities against cancer cell invasion and migration.

This concerns toxic, antimicrobial, defensin-like or immune system related with L1 motif[6] The current list of complex lasso proteins may be found in the LassoProt database,[5] which allows also uploading and analyzing own data.