A metastasis suppressor is a protein that acts to slow or prevent metastases (secondary tumors) from spreading in the body of an organism with cancer.
[4] MicroRNAs (miRNAs) are a class of gene regulators that bind the 3′ untranslated regions of target messenger RNAs, leading to either suppression of their translation or acceleration of their degradation.
[4] Metastasis suppressors can potentially serve as prognostic markers, therapeutic targets and predictors for treatment response.
[4] High NM23 expression is correlated with good prognosis in multiple tumor types, including breast cancer.
KAI1, PEBP1 and RECK expression correlate with improved survival in multiple tumor types, including colorectal cancer.
Treating human breast cancer cells with dexamethasone medroxyprogesterone acetate (MPA) increases NM23 expression.