[1] The term in silico was first used in 1989 at a workshop "Cellular Automata: Theory and Applications" by a mathematician from National Autonomous University of Mexico (UNAM).
[4] It became apparent that the techniques used to model biological systems has utility to explain and predict dynamics in the medical field.
The In Silico Oncology Group (ISOG)[9] at the Institute of Communication and Computer Systems, National Technical Institute of Athens (ICCS-NTUA) aims at developing clinically driven and oriented multiscale simulation models of malignant tumors (cancer) to be utilized as patient individualized decision support and treatment planning systems following completion of clinical adaptation and validation.
This EU-funded Horizon 2020 project proposes a cloud-based platform to support decision making in the clinical management of malignant solid tumours, offering predictive tools to assist diagnosis, prognosis, therapies choice and treatment follow up, based on the use of novel imaging biomarkers, in-silico tumour growth simulation, advanced visualization of predictions with weighted confidence scores and machine-learning based translation of this knowledge into predictors for the most relevant, disease-specific, Clinical End Points.
Additionally, there are projects underway that utilize virtual cadavers, computer simulated models of human anatomy based on CT images of real people.