Prior to 1905, students in Comstock Township had to travel to Kalamazoo or Galesburg to attend high school.

A gymnasium and auditorium was constructed on the campus in 1937 through a Public Works Administration project.

In 2005, voters rejected a 26-year bond proposal to replace the current high school, opting instead to renovate the building.

Students are encouraged to enroll in the many Advanced Placement courses offered, or to dual enroll at Kalamazoo Valley Community College or Western Michigan University to earn college credits prior to graduating high school.

1923 was the inaugural year for the Comstock High School football team, which ended its season with a 7-1-1 record.

In 2005 Comstock Varsity football completed its best season in school history; finishing 10-2 and winning the Wolverine Conference out right for the first time in almost 20 years.

In the fall of 2015, the junior varsity football team, led by freshman quarterback Brendon Blades and Coach Michael Small, won Comstock's first high school football game in four years, finishing the season 4-5.