In addition to Comstock, the district also serves the census designated places of Amistad and Box Canyon,[1] as well as the unincorporated areas of Juno, Langtry, and Pandale.
In 2007, the Texas State Energy Conservation Office awards Comstock ISD money due to the colonias served by the district.
[2] In 2009, the school district was rated "recognized" by the Texas Education Agency.
[4] On July 1, 1992, the Juno Common School District merged into Comstock ISD.
[5] In July 2024, the ACLU of Texas sent Comstock ISD a letter, alleging that the district's 2023-2024 dress and grooming code appeared to violate the Creating a Respectful and Open World for Natural Hair (or CROWN) Act, a Texas law which prohibits racial discrimination based on hair texture or style, and asking the district to revise its policies for the 2024-2025 school year.