Conca Casale is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 50 kilometres (31 mi) west of Campobasso and about 20 kilometres (12 mi) southwest of Isernia.

Conca Casale borders the following municipalities: Pozzilli, San Vittore del Lazio, Venafro, Viticuso.

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