She established one of the first women's organizations in the Philippines, Asociación Feminista Filipina, as well as one of the first humanitarian NGOs, La Gota de Leche, aimed specifically at the well-being of mothers and their children.

[1] The school had been founded by Felipe Gonzáles Calderón Roca, who drafted the Malolos Constitution[2][3] and who had been acting as a private tutor to Felix.

Like many of the 19th-century purity organizations, it sponsored drives against drinking, gambling, and prostitution and implemented moral campaigns in schools and factories[7] with lectures on hygiene, health, and infant care.

[10] Felix's idea was to establish a small maternity ward to train nurses and distribute sterile milk to sickly and malnourished infants.

[13] In 1933, a bill was passed giving women the right to vote, but a technicality which created the Philippine Commonwealth required that the process start over again.

[14][15] Continuing in the fight, along with Pilar Hidalgo-Lim, Josefa Llanes Escoda, Maria Paz Mendoza-Guazon, Constancia Poblete, Rosa Sevilla de Alvero, and Pura Villanueva Kalaw, Felix lobbied during the 1934 Philippine Constitutional Convention for women's suffrage.

[19] In 1948, Felix-Rodriguez received the Republic Medal of Merit and a diploma of honor, and the following year was recognized for her human rights work by UNESCO.