A populated area known as Arroyo de China (which had no foundation), was recorded in approximately 1778 and located north of the namesake creek in what are now the neighborhoods of Puerto Viejo and La Concepción in the extreme south of the city.

In 1814 the Supreme Director Gervasio Antonio Posadas, using the extraordinary powers given by the Constituent Assembly, named Concepción del Uruguay as the capital of the province of Entre Ríos at the time of its creation.

It was meant for the declaration of independence Argentina and the adoption of the flag created by Belgrano straddles the currency punzó-red diagonal stripe symbolizing federalism.

It was also decided not to attend Congress of Tucumán to be held the following year as a sign of protest toward Directory (unit) to promote the Portuguese invasion in Banda Oriental and attacks on federal deputies.

On February 1, 1820, General Francisco Ramírez, allied with the governor of Santa Fe Estanislao López, who commanded the federal army defeated José Rondeau at the battle of Cepeda, shortly after signing the Treaty of Pilar.

Subsequently, Ramírez was distanced from López and September 29 of that year, proclaimed the Republic of Entre Ríos, which included addition to the existing provinces of Corrientes and Misiones, Concepción being the capital of Uruguay.

In 1826, General Justo José de Urquiza, in his role as the governor of Entre Rios, promoted the law that gave Concepción del Uruguay range city.