Domingo Santo Liotta, the son of Italian immigrants, was born in the city of Diamante, Entre Rios, Argentina on 29 November 1924.

Liotta continued his medical career at the University of Lyon, France, at the "Pierre Mallet-Guy's" General Surgery Service.

After publishing the results of his studies, Liotta was hired at Baylor College of Medicine in Houston, Texas as Director of the Artificial Heart Program by Michael E.Bakey in 1961.

[4] As Secretary of Health he signed agreements with Chinese Premier Zhou Enlai and Israeli President Ephraim Katzir.

[citation needed] Liotta continued to actively work in research and development of new models of heart assist devices.