CIDOB was a member of the Pact of Unity from its founding until December 2011, when it left in protest of the Evo Morales government's response to its eighth march concerning the Isiboro Sécure National Park and Indigenous Territory.
The march was coordinated by Marcial Fabricano and began with around 300 participants, but swelled to some 800 indigenous people by the time of its arrival in La Paz on September 19.
CSUTCB and CSCB continued the march to La Paz, where some 13,000 marchers grew to twenty to forty thousand protesters, but were unsuccessful in winning the campesino federations' demands.
[10] In October and November 2006, CIDOB, the Bolivian Landless Workers Movement (MST-Bolivia), highland indigenous groups, and others joined in a National March for Land and Territory.
On 10 July, CIDOB president Adolfo Chávez was assaulted by right-wing protesters in Sucre's airport during a visit to present the organization's demands.
On July 26, 2011, CIDOB put forward a platform of demands for the Eighth March of the Indigenous Peoples of the East, Chaco, and Bolivian Amazon (Spanish: VIII Marcha Indígena de los Pueblos Indígenas del Oriente, Chaco y Amazonía Boliviana), which began in defense of the Isiboro Sécure National Park and Indigenous Territory against the planned construction of the Villa Tunari-San Ignacio de Moxos highway.
CIDOB's main demand was to roll back decrees that enabled land claims, deforestation, and burning, and it was conducted amidst the 2019 Amazon rainforest wildfires.