Under the leadership of the Túpac Katari Revolutionary Movement, the CSUTCB became an independent organization.
Through the CSUTCB's pressure, the COB moved beyond a purely class-based focus to address indigenous demands, as well.
The CSUTCB played a significant role in the series of demonstrations that brought down President Carlos Mesa in 2005.
The CSUTCB has supported nationalisation of Bolivia's natural gas reserves and opposed water privatization.
The CSUTCB was a founding member of the Pact of Unity supporting the Evo Morales government.