Route 163 is a state highway in southeastern Connecticut running from Montville to Bozrah.

It heads in a northwest direction and soon intersects I-395 (at exit 6) after half a mile.

It soon reaches the village of Oakdale, about 1.5 miles (2.4 km) later, where the road makes a few turns, crosses the Oxoboxo Brook, and continues northwest for another three miles (5 km) to reach Route 82 in northwest Montville.

In Bozrah, Route 163 veers to the northeast then continues for 4.5 miles (7.2 km) through rural areas before ending at an interchange Route 2 (at exit 23) west of the village of Fitchville.

In 1936, it was extended along former SR 655 to its current northern terminus at Route 2 in Bozrah.