Born in Italy, Di Nino immigrated to Canada with his family at the age of 13.
[citation needed] In 1990, Di Nino was appointed to the Senate on the recommendation of Prime Minister Brian Mulroney.
Di Nino has given a number of speeches and written letters urging a boycott of the People's Republic of China because of its occupation of that country.
[citation needed] Di Nino has also been heavily involved in the Italian-Canadian community as past chair of Villa Charities Incorporated (a charity founded by the Italian-Canadian business community), past president of the Canadian Italian Business and Professional Association, Villa Colombo Home for the Aged and the Columbus Centre of Toronto.
He also served as president of Harbourfront Corporation, a federal agency responsible for Toronto's waterfront.