Entering ecclesiastical service, he studied in Greece and received a Bachelor of Theology degree from the University of Athens.
On October 7, 1969, Constantine was elected Metropolitan Bishop of Baghdad and Kuwait by the Holy Synod of the Eastern Orthodox Patriarchate of Antioch and All the East.
On November 20, he visited the Kuwait parish, celebrating the liturgy on the next day in temporary facilities in the National Evangelical Church.
During the following years he established a number of Eastern Orthodox parishes within the Persian Gulf area, first in 1980 in Dubai and Abu Dhabi.
Because of bad health and advanced age, he decided to retire on 17 June 2014, and was succeeded by the new Metropolitan Ghattas Hazim.