The Consulate General serves the Indian states of Maharashtra, Gujarat, Madhya Pradesh, Chhattisgarh, and Goa.

In 1843, President Martin Van Buren issued a commission dated 5 October 1838 to Philemon S. Parker, of New York, as consul.

The palace was handed over to the U.S. consulate by the Maharaja to raise funds to pay off his taxes, after India became independent.

[4] In 2002, the consulate decided to shift its office to northern suburbs owing to security reasons.

Since 21 November 2011, all sections of the U.S. Consulate General Mumbai are located at a new facility in Bandra Kurla Complex.