The change in pH is especially pronounced with acidic fluid losses caused by problems like vomiting.
[citation needed] Another suggests that the alkalosis is due to renal compensatory mechanisms used to correct volume loss.
[citation needed] Finally, it has been suggested that the term "contraction alkalosis" is actually a misnomer, and that the alkalosis observed during volume contraction is actually attributable entirely to chloride depletion, which leads to a failure of pendrin, a chloride/bicarbonate exchanger in the collecting duct.
[3] Diagnosis of contraction alkalosis is made by correlating laboratory data with clinical history and examination.
[citation needed] Treatment consists of NaCl infusion to correct ECF volume contraction and administration of K+ to replace urinary losses.