CJM was started in Karachi with an aim to educate the girls of the clifton area, and has flourished ever since.

In addition to schooling the local Christian community, the Convent of Jesus and Mary, Karachi (along with its affiliate schools in Lahore, Murree, Mariakhel, Shadbagh, Sialkot, and Toba Tek Singh) have long been Pakistan's most elite all-girls educational institution.

It has schooled influential women, including Pakistan's first female prime minister, other leaders, social workers, activists, professionals, entrepreneurs, writers, entertainers, philanthropists, home-makers, and a countless number of women in the creative arts.

[2] The government of Sindh presented land in Karachi to the sisters in appreciation of their educational work in the country.

Governor Ishrat-ul-Ebad Khan of Sindh presented the 99-year lease papers for 1.5 acres (0.61 ha) to the Sisters during a ceremony on 24 September at Government House, Karachi.