In the quarter-finals: The two teams had met in four previous encounters, the latest being a friendly held at the Estadio Ramón Tahuichi Aguilera in Santa Cruz, which Panama won 3–1.
Man of the Match:[2] Blas Pérez (Panama) Assistant referees:[3] Octavio Jara (Costa Rica) Juan Carlos Mora (Costa Rica) Fourth official:[3] Wilson Lamouroux (Colombia) Fifth official:[4] Peter Manikowski (United States) The two teams had met in eighty-six previous occasions, the last being a 2018 FIFA World Cup qualifying match held at the Estadio Nacional Julio Martínez Prádanos in Santiago in early 2016, which Argentina won 2–1.
Man of the Match:[6] Ángel Di María (Argentina) Assistant referees:[3] Nicolás Taran (Uruguay) Richard Trinidad (Uruguay) Fourth official:[3] Jair Marrufo (United States) Fifth official:[4] Corey Parker (United States) The two teams had met in forty-one previous occasions, the last being a 2015 Copa América group stage match won by Chile 5–0.
Man of the Match:[10] Lionel Messi (Argentina) Assistant referees:[3] Juan Zumba (El Salvador) William Torres (El Salvador) Fourth official:[3] Víctor Carrillo (Peru) Fifth official:[3] Coty Carrera (Peru) The two teams had met in three previous occasions, the last being a friendly held at the Estadio Municipal Francisco Sánchez Rumoroso in Coquimbo in 2010, which Chile won 2–1.
Man of the Match:[12] Eduardo Vargas (Chile) Assistant referees:[3] Byron Romero (Ecuador) Luis Vera (Ecuador) Fourth official:[3] Wilmar Roldán (Colombia) Fifth official:[3] John Alexander León (Colombia) The two teams had met in thirty-six previous occasions, the last being a 2018 FIFA World Cup qualifying match held at the Estadio Mario Alberto Kempes in Córdoba in early 2016, which Argentina won 2–0.