The knockout stage of the Copa América Centenario began on June 16 and concluded on June 26, 2016 with the final at MetLife Stadium in East Rutherford, New Jersey.
The top two placed teams from each of the four groups qualified for the knockout stage.
[1] Man of the Match:[3] Clint Dempsey (United States) Assistant referees:[4] Alexander Guzmán (Colombia) Wilmar Navarro (Colombia) Fourth official:[4] Wilton Sampaio (Brazil) Fifth official:[4] Juan Pablo Montaño (Bolivia) Man of the Match:[6] David Ospina (Colombia) Assistant referees:[4] Ezequiel Brailovsky (Argentina) Ariel Scime (Argentina) Fourth official:[4] Mark Geiger (United States) Fifth official:[4] Charles Morgante (United States) Man of the Match:[8] Lionel Messi (Argentina) Assistant referees:[4] José Luis Camargo (Mexico) Alberto Morín (Mexico) Fourth official:[4] Ricardo Montero (Costa Rica) Fifth official:[4] Christian Ramírez (Honduras) Man of the Match:[10] Eduardo Vargas (Chile) Assistant referees:[4] Kléber Lúcio Gil (Brazil) Bruno Boschilia (Brazil) Fourth official:[4] José Argote (Venezuela) Fifth official:[4] Luis Sánchez (Venezuela) Man of the Match:[12] Lionel Messi (Argentina) Assistant referees:[4] Eduardo Cardozo (Paraguay) Milciades Saldívar (Paraguay) Fourth official:[4] Roddy Zambrano (Ecuador) Fifth official:[4] Luis Vera (Ecuador) Due to heavy thunderstorms in the Chicago area which arrived shortly after the first half ended, the start of the second half of the match was delayed by over two hours.
[13] Man of the Match:[15] Charles Aránguiz (Chile) Assistant referees:[4] Juan Zumba (El Salvador) William Torres (El Salvador) Fourth official:[4] José Argote (Venezuela) Fifth official:[4] Luis Murillo (Venezuela) Man of the Match:[17] David Ospina (Colombia) Assistant referees:[4] Richard Trinidad (Uruguay) Luis Sánchez (Venezuela) Fourth official:[4] Yadel Martínez (Cuba) Fifth official:[4] Gabriel Victoria (Panama)
Man of the Match: Claudio Bravo (Chile)[19] Assistant referees:[4] Kléber Lúcio Gil (Brazil) Bruno Boschilia (Brazil) Fourth official:[4] Roberto García (Mexico) Fifth official:[4] José Luis Camargo (Mexico)