Cope is a town in Orangeburg County, South Carolina, United States.

Cope Depot was added to the National Register of Historic Places in 2001.

[6] According to the United States Census Bureau, the town has a total area of 0.2 square miles (0.52 km2), all land.

21.1% of all households were made up of individuals, and 2.6% had someone living alone who was 65 years of age or older.

There were 20.0% of families and 24.4% of the population living below the poverty line, including 36.2% of under eighteen and 21.4% of those over 64.