The Coquille River is a tributary of Nicabau Lake, flowing into the unorganized territory of Lac-Ashuapmushuan, Quebec, into the Regional County Municipality (RCM) of Le Domaine-du-Roy, in the administrative region of Saguenay-Lac-Saint-Jean, in Quebec, in Canada.

A secondary forest road (heading north-east) that connects to route 167 serves the upper part of the "Coquille River" valley passing north of Lake Liasse and South of "Coquille Lake".

Route 167 between Chibougamau and Saint-Félicien, Quebec passes on the west side of the lower part of the river.

The surface of the Coquille River is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

From there, the current flows south-east along the Normandin River on 38.7 kilometres (24.0 mi) to the northwestern shore of Ashuapmushuan Lake.