Webster was selected by the Giants in the second round of the 2005 NFL draft and later won two Super Bowls with the team, both over the New England Patriots.

He was recruited as a wide receiver coming out of high school but was later asked to play cornerback at LSU by then coach Nick Saban.

In the Wild Card Playoff game against the Tampa Bay Buccaneers, he intercepted Jeff Garcia in the end zone.

He also made what turned out to be the game-winning interception against the Green Bay Packers in the NFC Championship game, sending the Giants to Super Bowl XLII.

But, he came back to deflect a pass from Tom Brady to Randy Moss on the next drive to prevent the Patriots from scoring, and all but securing the Super Bowl victory.

[12] On December 27, 2023, over a decade after his last NFL snap, Webster announced that he would sign a one-day contract to retire as a Giant.