Economic activities along the river are impacting its water quality.

Agricultural along the river is using agrochemicals, which are contaminating the water,.

Gold mining , mostly illegal, is difficult to control and leads to heavy pollution of the Río Coroico with mercury and other chemicals.

Evergrowing settlements in the watershed are facing a huge challenge to build waste infrastructure.

The wastewater from the most densely populated settlements is also discharged untreated into the Río Coroico.