The band has undergone multiple lineup changes throughout its existence, with lead guitarist Woody Weatherman as the sole constant member.

[7] More lineup changes have happened since then, with John Green replacing Mullin after his death in 2020 and Dean (who first left Corrosion of Conformity in 1987 and rejoined in 1993) departing from the band once again in 2024.

Corrosion of Conformity found success with the release of their 1994 fourth studio album, Deliverance, which peaked at number 155 on the Billboard 200 and spawned the hits "Albatross" and "Clean My Wounds".

[9] Corrosion of Conformity was formed in Raleigh, North Carolina, by bassist and vocalist Mike Dean, guitarist Woody Weatherman, drummer Reed Mullin, and singer Benji Shelton in 1982.

"[11][12][13] They released tracks on the No Core cassette tape compilation on the label of the same name along with other North Carolina punk bands in 1982 as well as on the "Why are we here?"

[15][clarification needed] COC recruited Simon Bob Sinister to replace Dean, after the breakup of their fellow Carolina band and Death Records labelmates Ugly Americans.

The band's 1987 release, the Technocracy EP, featured the hectic crossover thrash musicianship of COC with a cleaner vocal style than they had in the past.

This was mainly due to the singles "Albatross" and "Clean My Wounds" becoming Top 20 hits on rock radio and the album managed to spend almost four months on the Billboard 200, peaking at No. 155.

Over the next few years, the band worked with a series of drummers: Jimmy Bower of Eyehategod, local Raleigh percussion professor Merritt Partridge, Stanton Moore of Galactic and Reed's former drum technician Jason Patterson, who previously played drums in the Raleigh-based rock band Cry of Love.

They were the opening acts for Motörhead and Disturbed and also went on headlining tours with Crowbar, Fu Manchu, Alabama Thunderpussy, and Danko Jones all providing support.

Reed Mullin and Mike Dean along with Jason Browning also toured in a new band called "Righteous Fool", and have released a self-titled EP through Southern Lord Records.

In September 2012, Corrosion of Conformity posted three pictures from the studio on Facebook, stating that they were working on a five-song EP called Megalodon with Mike Schaefer and John Custer.

[29] Corrosion of Conformity performed their first show with the re-united Deliverance era lineup of Pepper Keenan, Woody Weatherman, Mike Dean, and Reed Mullin on March 7, 2015, in Manchester, England.

[31] On June 6, 2016, Corrosion of Conformity announced the letting go of drummer Reed Mullin after a prolonged battle with alcohol addiction, resulting in a seizure before their concert in Edmonton, Canada on the Lamb of God and Clutch tour.

[34] His replacement was immediately announced to be John Green from Manchester, England, who had previously worked as the band's roadie and stepped in as a stand-in in 2019 for numerous shows.

[35] Longtime bassist Mike Dean announced his second departure from Corrosion of Conformity on September 20, 2024, citing difficulties coping after Mullin's death and living "hundreds of miles away" from the remaining members of the band as factors.

[8] They have also collaborated with a number of other artists: James Hetfield of Metallica contributed vocals to the song "Man or Ash" on Wiseblood; Warren Haynes of the Allman Brothers' Band and Gov't Mule played slide guitar on "Stare Too Long" on America's Volume Dealer; and Stanton Moore of Galactic played drums on In the Arms of God.

Members of COC have also participated in collaborations: Keenan plays guitar with the metal supergroup Down, and Dean contributed vocals to a track titled "Access Babylon" on Dave Grohl's Probot project.

Pepper also appears on Metallica's Garage Inc. cover record, playing guitar and singing the second verse of the Lynyrd Skynyrd song "Tuesday's Gone".