Pepper J. Keenan (born May 8, 1967) is an American guitarist and vocalist, best known for his work with heavy metal bands Corrosion of Conformity and Down.

In 1991, Keenan formed Down with Phil Anselmo of Pantera, Jimmy Bower of Eyehategod, and Kirk Windstein and Todd Strange of Crowbar.

Keenan was born in Oxford, Mississippi, but now lives in New Orleans, Louisiana, where he owns a bar named "Le Bon Temps Roule".

Keenan was a founding member of Down in 1991 along with Pantera's Phil Anselmo, Eyehategod's Jimmy Bower, and Crowbar's Kirk Windstein and Todd Strange.

Keenan plays guitar and sings a part of the second verse on Metallica's cover of the Lynyrd Skynyrd song "Tuesday's Gone".

Keenan auditioned for Metallica's vacant bass player position following Jason Newsted's departure from the band but lost out to former Suicidal Tendencies/Ozzy Osbourne bassist Robert Trujillo.