Corticopontine fibers are projections from layer V of the cerebral cortex to the pontine nuclei of the ventral pons.

[1] They represent the first link in a cortico-cerebello-cortical pathway mediating neocerebellar control of the motor cortex.

[2] All corticopontine fibers arise from pyramidal neurons in layer V of the cerebral cortex.

The fibers descend through the sublenticular and retrolenticular of internal capsule, then traverse the midbrain through the basis pedunculi (i.e. ventral part of cerebral peduncle) to reach the pontine nuclei and synapse with neurons that give rise to pontocerebellar fibers.

[2] As the corticopontine fibres descend in the cerebral peduncle, those from the prefrontal regions are situated most medially; those from premotor and motor cortices are situated in the middle third of the peduncle, and fibers from the parietal, temporal and occipital regions that travel to the pons are in the lateral third of the cerebral peduncle.