[1] Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers.
It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM),[2] antiallergic, antinociceptive, and gastric emptying activities.
Corydaline exhibited strong nematocidal activity, showed little cytotoxicity and represents a potential treatment for Strongyloidiasis.
Corydaline is nematocidal against S. ratti and S. venezuelensis third instar larvae with 50% paralysis (PC50) values of 18 and 30 μM, respectively.
Additionally, this compound may inhibit mast cell-dependent smooth muscle contraction of the aorta.