Corymbia nesophila is a tree that typically grows to a height of 7 to 30 metres (23 to 98 ft) and forms a lignotuber.

It has rough, fibrous, greyish brown, tessellated to crumbly bark on the trunk and branches.

[2][3][4][5][6] The Melville Island bloodwood was first described in 1934 by William Blakely who gave it the name Eucalyptus nesophila and published the description in his book A Key to the Eucalypts.

[6][8] Corymbia nesophila has a disjunct distribution throughout the tropical north of Australia and is common in the east Kimberley region of Western Australia, the top end and islands off the coast of the Northern Territory and on the Cape York Peninsula of Queensland.

It grows on basalt or laterite on the lower slopes and flat areas with sandy or sandy-loam soils.