From its source in the Parinacota Province, the river flows north, is part of the Chile-Bolivia boundary and then flows in the Bolivian Department of Oruro.

The Caquena river has its source at the Payachata volcanic group, flows to north, it is part of the Chile-Bolivia boundary, and meets the Cosapilla and takes this name.

After about 20 kilometres (12 mi) in Bolivian territory, it empties into the Uchusuma River.

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