[7] During the 15th century, the humanist movement had taken hold of Italy, and women of affluence were able to receive an education that encouraged writing and speaking with eloquence and clarity.

While women were a small minority in the humanist movement during their time, their contribution to the development of the Renaissance and evolution of intellectual life in modern Europe was significant.

[10] Varano was educated in both Latin and Greek, and her knowledge was considered exceptional compared to other women in 15th century Italy.

[4] Despite the transaction-centered arrangement, it is believed that Alessandro truly loved Varano, and acquired Pesaro in part to win her heart.

[14] Varano, her grandmother, mother and daughter were all politically involved women, often speaking publicly on their families' behalf because their male counterparts could not.

[4] Learned women of the time typically demonstrated low self-confidence in their works through self-deprecation and Varano was no exception.

[17] She was praised in her time by male humanists, who were often impressed by learned women because they were so rare, and because their eloquence and clarity was comparable to their own.

[13] Her poem to Oddantonio da Montefeltro and verses to Gianlucido Gonzaga in 1443 are political, seeking the return of land to her family as her speech to Bianca did.

[23] Like other notable female scholars in early modern Northern Italy to whom she is compared (Ginevra Nogarola and Caterina Caldiera, for example), Costanza married and her Latin humanist education ceased.

[6] Costanza, along with being a writer, scholar and orator, improved the education system in Pesaro when she invited teachers to the city.

[12] Her family's grammar teacher, Giacomo da Pesaro, dedicated his De octo partibus orations to Costanza, and after her death, many eulogies were written to praise and celebrate her fame and intellect.