[2] After completing in 1920 his secondary studies at Gheorghe Lazăr High School, Nenițescu continued his studies at the Polytechnic Institute in Zurich and Ludwig Maximilian University in Munich, where he completed in 1935 his Ph.D. under the direction of Hans Fischer,[1][3] with thesis regarding the synthesis of degradation products of blood pigments.

He searched for ways of obtaining cyclobutadiene, while explaining the chemistry of this unstable substance and isolating its dimers.

[8][9] In 1969, he was nominated for the Nobel Prize in Chemistry "for discovering two new syntheses for the indolenucleus, and a new method of polymerisation of ethylene".

[8] A student of his, she obtained her Ph.D. in chemistry in 1936, became a professor at Politehnica University, and was elected titular member of the Romanian Academy in 1974.

Built by his father in 1908 in the Romanian Revival style, the house was declared a historic monument in 2010, but was abandoned soon after and caught fire in 2016.