The hospital has been closed in 1942 after a series of burning and in 1944 when American Forces started bombing the town of Cotabato.

[1] Gatmaitan approved the acquisition of a new site in 1975 which had an area of 101,611 m2 (1,093,730 sq ft; 10.1611 ha) from the Canizares Estate.

[1] By virtue of Republic Act 8316, the hospital was again upgraded into a 400-bed capacity medical center and named Cotabato Regional and Medical Center and was approved as Level IV Tertiary, Teaching, and Training hospital.

Further health facility enhancement was accomplished by the construction of Oxygen Generating Plant and the DILANGALEN Cancer Care Center.

Enrique T. Ona Wing with 25 single (standard and suite) rooms and an elevator shaft was completed.