Václav Antonín Chotek of Chotkov and Vojnín was born in Bělušice, Bohemia, on 26 February 1674.
He was son of Vilém Chotek of Chotkov and Vojnín (1628–1674) and his second wife Johanna Sabina Proy von Gaiselsberg und Findtelstein (1650–1692).
He married Maria Theresia Ludmilla Scheidler von Scheidlern (1684–1709) on 28 October 1698, in Prague.
Maria Theresia was daughter of Ferdinand Christoph (Ritter) Scheidler von Scheidlern, captain of the Prague quarter Malá Strana and High Chamberlain (nejvyšší zemský komorník; Oberstlandkämmerer) of the Kingdom of Bohemia.
He was father of sevel children, including: On 6 February 1702, Václav Antonín Chotek Ritter (Knight) of Chotkov and Vojnín was received into the Bohemian nobility in Vienna.