He was the regent of the Kingdom of Navarre and Seville, professor at the University of Salamanca, Lord of the House of Medrano and fortress of San Gregorio and of the Council of Castile and Chamber of the King, who married doña María Ignacia de Mendizábal y Uribe, a native of Granada (daughter of Greg de Mendizábal, a native of Oñate, Knight of the Order of Santiago and of the Royal Council of Castile, and doña Teresa de Uribe, a native of Lequeitio, Vizcaya).

García José Francisco de Medrano y Mendizábal was born in Madrid on September 7, 1652, and died on March 3, 1695.

[31][30] Andrés de Medrano y Mendizábal[32] (1654–1720) of Seville, later residing in Madrid, was granted knighthood in the Order of Calatrava in 1690.

He had a distinguished career serving King Charles II, holding positions such as Secretary of State and member of the Council of Castile.

Andrés de Medrano y Mendizábal owned a portrait of King Charles II, and of the regent, Mariana of Austria (d. 1696).

His collection was made up almost entirely of religious paintings, including a picture by Mateo Cerezo of the miraculous statue of Christ from Burgos.

Details of his art collection, including portraits of King Charles II and Mariana of Austria, along with religious paintings predominately featuring works by Mateo Cerezo and Luca Giordano, are documented in an estate partition dated August 12, 1724, in Madrid.

Notable pieces include a Nativity of Christ by Luca Giordano and an unfinished work by El Greco.

It is speculated that some of the older works by El Greco and copies after Titian and Jusepe de Ribera may have been inherited rather than acquired directly by Medrano himself.

[33] José Juan de Medrano y Angulo (died in 1765), III Count of Torrubia, IV Marquéss of Villamayor, barón of Purroy, Lord of San Gregorio.

He was succeeded by his son: Joaquín José María de Medrano y Luján[35] (died in 1799), IV Count of Torrubia, V Marquess of Villamayor, Lord of San Gregorio.

The municipalities which comprise the Marquisate of Las Nieves are: Alozaina, Casarabonela, El Burgo, Guaro, Istán, Monda, Ojén, Tolox and Yunquera.