Medrano is a Spanish surname of Basque origin that means "abundance, to grow, to prosper, or to improve."

It is a surname of high nobility established in the old Kingdoms of Navarre, Aragon, Castile, France, etc.

[1] They are all descendants of their progenitor, Prince Andrés Vélaz de Medrano.

[1][2][3][4][5][6] Medrano may refer to: Notable people with the surname include: Some of the noble titles held by the Medrano family, though not limited to, include: