[4] Luisa de Medrano came from a family of Castilian high nobility who were protected by King Ferdinand II and Queen Isabella of Castile.

Juan Bravo's wife Catalina Núñez de Cienfuegos, on the occasion of the death of her husband and son-in-law in that action, received a heartfelt letter of condolences and gratitude from the Catholic Monarchs on June 7, 1487.

Their livestock, which included 15,000 sheep,[9] grazed in those lands, and hundreds of times they walked to the pastures of Extremadura or the royal valley of Alcudia, in La Mancha.

[13] Luisa's portrait was featured on the front cover of the 2nd Edition of the International Women’s Day event in Castilla-La Mancha, held in Tomelloso on March 8, 2018.

[12] Widely recognized as the first female 'professor' in Europe,[1] Luisa de Medrano's intellectual abilities and solid formation enabled her to teach Latin at the University of Salamanca.

[15] Her greatest protector and patron, Queen Isabella of Castile, ultimately enabled Luisa de Medrano to teach Latin at the University of Salamanca.

Luisa de Medrano not only received a privileged and nurtured education with the royal daughters, Isabel and Juana, she undoubtedly benefited from living in the climate of tolerance and advancement for women that Isabella I actively cultivated in her court, and which disappeared after her death.

Under the protection of Queen Isabella I, Luisa de Medrano learned history, culture and humanist philosophy alongside children of the royal family.

[19] Isabel I's grandson, Emperor Carlos I of Spain, Karl V of Germany, tried to rid the world of the memory of his mother Joanna I and of other women as well, including Luisa de Medrano.

In the Chronicle Registry of Salamanca in 1513, a testimony by Pedro de Torres says: The scholar Lucio Marineo Siculo misspelled her name, using Lucía, instead of Luisa.

You, my dearest girl, owe much to the Almighty God, who has bestowed great talents upon you, and also to your parents, who have not assigned you to the ordinary duties of women, nor to the unpleasant toils of the body, which are quickly destroyed, but have freed you for the pursuit of the most illustrious studies and arts, and have consecrated you to eternal memory.

1710), priest, historian and professor of theology,[22] said: "Doña Luisa de Medrano, if she did not equal, exceeded the first (B. Galindo), since she not only knew Latin perfectly, but also publicly spoke in this University in Divine and Human Letters.

"[23] The famous Spanish explorer and conquistador Gil González Dávila, in his Ecclesiastical Theater of the Metropolitan and Cathedral Churches of the Kingdoms of the Two Castiles, says: "Doña Luzía (Luisa) de Medrano: Marineo Siculus speaks of her as having heard her teach in the University of Salamanca and seen her pray in public, and that she was a woman of rare and admirable eloquence.

"[24] On 23 April 1943, the Ministry of National Education of Spain granted, at the proposal of the Cloister of the National Institute of Secondary Education of Salamanca, female, that this Institute be called "Lucía de Medrano," and on October 12, 2015, the Rectorate and the University of Salamanca agreed that the Hall of Cloisters of the Higher Schools of the university be named "Lucía de Medrano" to honour the first female professor in Spain and Europe.

In the "Memoirs of the Royal Academy of History" (1821), Clemencín praises her erudition and eloquence, noting that Marineo Sículo described her as publicly explaining the classics in Latin at the University of Salamanca.

[26] Don Manuel Hermenegildo Dávila, in his "Historical Review of the University of Salamanca" (1849), refers to documents that affirm Doña Luisa de Medrano's role as a professor, lecturing on pure Latin authors.

[28] Villar y Macías, in the "History of Salamanca" (1887), volume II, quotes Marineo Sículo, who heard her lectures and admired her rare eloquence.

[29] Menéndez y Pelayo, in his "Anthology" (1896), volume VI, acknowledges her as a professor, citing her inclusion in the letters of Lucio Marineo and the "Gynaeceum Hispanae Minervae" by Don Nicolás Antonio, recognizing her as a distinguished female scholar dedicated to the Latin classics.