The highway extends 21 miles (34 km) from Route 27 in South Brunswick Township to Main Street (CR 537) in Freehold Borough.

At this point, Promenade Boulevard ends and CR 522 turns south to form a concurrency with US 130 on a four-lane divided highway, passing businesses.

CR 522 splits from US 130 at an interchange and heads east on two-lane undivided Ridge Road, running past several distribution warehouses and a couple farms.

Past CR 612, the road continues southeast on Bucklew Avenue through neighborhoods before leaving Jamesburg for Monroe Township again.

After crossing CR 3 (Tennent Road), the route passes through fields and woods within Monmouth Battlefield State Park.

Upon entering Freehold Borough, CR 522 becomes municipally maintained Thockmorton Street, which turns southeast into residential areas.