The highway extends 16.88 miles (27.17 km) from Union Avenue (Route 28) in Bound Brook to Main Street (CR 510) in Mendham Borough.

CR 525 begins at Route 28 in Bound Brook, located 8 miles (13 km) northwest of New Brunswick in Somerset County.

In Liberty Corner, CR 525 intersects County Route 512 while becoming Mount Airy Road.

North of Liberty Corner, CR 525 changes its alignment to a northwest course while meeting with Interstate 287 at exit 26.

CR 525 enters the borough of Mendham with a couple of wide turns before terminating at an intersection with County Route 510.