[2] CR 583 begins at the border of Trenton and Ewing Township along two-lane undivided Princeton Avenue (southbound US 206) just northeast of the Prichard Street intersection.

From the southern terminus, the road runs northeast concurrent with southbound US 206 through residential and commercial areas, forming the border between Ewing Township to the northwest and Trenton to the southeast.

In Lawrence Township, Princeton Avenue comes to the CR 645 intersection that provides access to the Brunswick Circle and US 1 Business.

After an intersection with CR 546, the route passes business parks and widens into a divided highway as it reaches a cloverleaf interchange at I-295.

The road enters Princeton, where it becomes Mercer Street, and briefly gains a median prior to crossing CR 533.