C. burnetii Coxiella refers to a genus of Gram-negative bacteria in the family Coxiellaceae.

Genomes of Coxiella-like endosymbionts encode pathways for the biosynthesis of major B vitamins and co-factors that fit closely with the expected nutritional complements required for strict haematophagy.

[4] The experimental elimination of Coxiella-like endosymbionts typically results in decreased tick survival, molting, fecundity and egg viability, as well as in physical abnormalities.

[5] Seven conserved signature indels (CSIs) were identified through genomic analyses[6] as exclusively shared by C. burnetii and other unnamed Coxiella-related species in the proteins glutamine-hydrolyzing GMP synthase, type I methionyl aminopeptidase, ribonucleoside-diphosphate reductase subunit alpha, translation initiation factor IF-3, phosphomannomutase-phosphoglucomutase, LPS export ABC transporter ATP-binding protein, and NADH-quinone oxidoreductase subunit G. These CSIs serve to reliably demarcate the genus from other Legionellales species in molecular terms.

[6] Additionally, three CSIs were identified as uniquely shared between the genus Coxiella, and two other genera belonging to the family Coxiellaceae, Diplorickettsia and Rickettsiella.