Coxsackie (/kʊkˈsæki/ kuuk-SAK-ee[3]) is a town in Greene County, New York, United States.

The name of the town is said to be derived from a Native American term, but it has various translations ("owl's hoot" is locally common).

The settlement of Coxsackie began in the seventeenth century, in approximately 1652, as part of the development of New Netherland.

Further land was lost in the formation of the newer towns of Cairo and Greenville (1803), New Baltimore (1811), and Athens (1815).

In 1663, he built the Pieter Bronck House in West Coxsackie, which is open as a museum.

The eastern town line is defined by the Hudson River and is the border of Columbia County.

State Route 385, running north-south through the town, serves the older villages and other areas near the Hudson River.