Development began in August 2018 with Chris McKay as producer and Jon and Josh Silberman writing the screenplay.

Discovery again considered shelving the film and claiming a tax loss, although in March 2024 it was revealed by Burch that conversations within Warner Bros.

[13] Director Dave Green confirmed that many Looney Tunes characters, outside of Wile E. Coyote himself, appeared "in significant supporting roles and in bit cameos" throughout the film.

[15] In mid-December 2019, Warner Animation Group hired Dave Green to direct the live-action/animated hybrid film,[16] while Jon and Josh Silberman were replaced as screenwriters, but remained producers.

[5] Along with the departure of McKay, it was reported that the film draws inspiration from the fictional 1990 New Yorker article of the same name by Ian Frazier.

[18][19] In December 2022, Bugs Bunny, Daffy Duck, Elmer Fudd and Yosemite Sam were also confirmed to be in the film.

[26][27] The creative team acknowledged Who Framed Roger Rabbit (1988) as a reference for the film's live-action interaction with animated characters.

[28] New Mexico Film Office director Amber Dodson commented in a press release that the production would "showcase our beautiful city as an already iconic location and setting in the Looney [Tunes] cartoons".

[29] Visual effects and computer animation were provided by DNEG for Wile E. Coyote and other significant Looney Tunes characters.

[30][31] According to Green, the 3D animators worked closely with a team of 2D artists, who guided them with drawn poses and expressions of the characters in order to "[find] the building blocks of performance".

[32] Editor Carsten Kurpanek explained that "artists would do [black-and-white] line drawings of key poses over a rough edit first", which were later used as reference for visual effects and animation; this process was dubbed "sketchviz" by the crew, bearing similarities to one of Warner Animation Group’s previous films Tom & Jerry.

[39][40] Director Dave Green voiced his disappointment over the film's cancellation, further emphasizing his love for the Looney Tunes and writing that "We were all determined to honor the legacies of these historic characters and actually get them right.

[37][44] TheWrap reported that despite interest from distributors to buy the film, there are "currently no hard offers, and that Green is crafting his own 'PR campaign'".

The company considered shelving and deleting the film (which remained in limbo at the time) and again claiming it as a tax loss.

[53] On March 10, 2024, during the red carpet for the 96th Academy Awards, Burch said conversations were still ongoing within Warner Bros. and that "we hope it will somehow find its home and not end up stuck in a vault for the rest of time".

[47] Bauza addressed this in an improvised exchange between Bugs Bunny and Daffy Duck during his speech at the 51st Annie Awards, with him saying "I hate to be political, but release Coyote vs.

[56][57] Industry figures who saw Coyote vs. Acme included Phil Lord and Christopher Miller, Michael Chaves, and Daniel Scheinert.

"[59] In February 2024, Forte released a public statement addressed to the cast and crew after seeing the final cut of the film: "I know that a lot of you haven't gotten a chance to see our movie.