In December 2019, Netflix announced a second season, entitled Green Eggs and Ham: The Second Serving,[6] which was released on April 8, 2022,[7][8] and is a loose adaptation of The Butter Battle Book.

[9] In Season 1, Sam-I-Am rescues a rare Chickeraffe from a zoo, saying that he intends to return it to its natural habitat.

The four are pursued by Mr. Hervnick Z. Snerz, a tiny evil poacher and collector, who wants to claim the Chickeraffe (named Mr. Jenkins by E.B.)

set off on another adventure to East Flubria to find Sam's biological mother Pam-I-Am, who reveals that she is stopping the nations of Yookia and Zookia, which are at war with one another as a precious orb-like object (the Moo-Lacka-Moo) is stolen by her.

At the same time, Deadline Hollywood reported that production on the series would take three years and was expected to be the most expensive animated program to make with each episode costing five to six million dollars.

[10] On December 21, 2019, Netflix renewed the series for a second season with 10 episodes loosely based on The Butter Battle Book as revealed from the trailer on March 10, 2022.

[11] On February 19, 2019, the cast of the series was announced with Adam DeVine and Michael Douglas voicing the lead roles while Diane Keaton, Ilana Glazer, Eddie Izzard, Tracy Morgan, Daveed Diggs, John Turturro, Jeffrey Wright and Jillian Bell would have supporting roles.