Crassula cotyledonis is a succulent plant endemic to the arid Namaqualand and Karoo regions of South Africa.

However, C. cotyledonis can always be distinguished by the cilia on the margins of the infertile bracts lower on its peduncle, which are not in one single row.

The cilia on the margins near the tips of the leaves is similarly irregular and not in a single line.

Other key diagnostic characters are the obovate or oblanceolate leaves having rough, backwards-curved hair, and the inflorescence having 3 to 6 infertile bracts near its base.

This species occurs from Worcester, through the Karoo regions as far east as the Eastern Cape Province, and north as far as Namibia.