Located on the Pavia–Mantua railway, it is terminus of the lines linking Cremona with Treviglio, Brescia, Piacenza and Fidenza.

Cremona railway station is situated at Via Dante, at the northern edge of the city centre.

[1] The passenger building at the station consists of a central section and two lateral wings, all of which are on two levels.

Tracks 3 and 4 are served by an island platform equipped with shelters and linked with the passenger building by two underpasses.

[2] Cremona is the terminus of regional services originating from Milan and Treviglio, from Brescia, from Piacenza and from Fidenza.