[2] The primary successive incarnation, known as the Crime Syndicate of Amerika (with the variant spelling of America), first appeared in the 2000 JLA: Earth 2 graphic novel.

It initially had no superheroes, only the supervillains of the Crime Syndicate, though this changed with the later introduction of the heroic Lex Luthor who used his vast intelligence for good.

Following this defeat, the JLA freed the captured JSA heroes and imprisoned the CSA in an unbreakable bubble generated by Green Lantern's power ring that was placed in a "limbo" dimension between the Earths, where time has no meaning.

When they inevitably tried to double-cross him, a safety protocol he had created hurled the traitors uncontrollably into the time stream, where they landed coincidentally on the satellite headquarters of the JLA in the then-present day of 1982 (the year the story was published).

The heroes succeeded in stopping Per Degaton and the CSA before their evil plan could be set in motion, effectively wiping these events from existence and everyone's memory.

[12] During the Convergence storyline, the Crime Syndicate had accidentally killed the Earth-Three version of Bruno Mannheim where Superwoman was arrested and sentenced to death.

Despite the dome being over their Metropolis, Ultraman, Owlman, Power Ring, and Johnny Quick worked to infiltrate the prison and free Superwoman.

The Crime Syndicate's Post-Zero Hour antimatter Earth possesses a "reversed" history similar to Earth-Three's, but with a much darker tone to both the team and its world.

Unlike the Crime Syndicate of Earth-Three, this Crime Syndicate of Amerika are able to rule their world (a change from their Pre-Crisis counterparts, who were unsuccessful in conquering their world) though they allow governments to continue operating and honest people are able to continue operating in pockets such as Gotham City Police Commissioner Thomas Wayne Sr. (father to Owlman and counterpart of the murdered father of Batman).

When Superwoman arrives on the scene, adamant that she has never given birth, it is revealed that the superpowered infant is actually a reborn Brainiac from the antimatter universe, defeated by Ultraman in the Earth-2 story.

[16] During their decimation of the planet, the entire Antimatter universe undergoes a reboot which causes some immediate changes, the most obvious of which is the sudden replacement of the white Power Ring with a black counterpart to John Stewart, the then-current Green Lantern in the JLA.

Not knowing of these events, the Crime Syndicate journey to the matter universe to attack Earth, blaming the JLA in the mistaken belief that the heroes are responsible for the changes that they have endured.

Meanwhile, the defeated Qwardians rally behind a dimension-destroying weapon called the Void Hound and pursue the Syndicate to the matter universe, laying waste to hundreds of planets along the way.

The heroes finally defeated the Void Hound by using a former JLA foe, the Construct, to remove the artificial intelligence of the massive weapon and render it powerless.

With the Void Hound defeated and the CSA owing the JLA a favor for saving them, the villains are sent back to the antimatter universe, where they discover to their horror that the Qwardians have also invaded their Earth, dismantling their entire criminal organization and freeing many imprisoned superheroes and rival supervillains.

Set years before Superman and Batman knew each other's secret identities, a vacationing Clark Kent, Bruce Wayne, and Lois Lane meet Ultraman, Owlman, and Superwoman when the villains appear on a cruise ship.

[18] It is also revealed that Saturn Queen, last seen in "Absolute Power",[19] survived the reboot of the universe in Infinite Crisis and through flashbacks we learn that she has used her telepathic abilities to convince Ultraman that he is Kal-El and that she is his mother.

Kara eventually breaks free and in a blind rage beats him to a pulp (at this point in time, Supergirl was portrayed as being slightly more powerful than Superman).

Ultraman is saved when Saturn Queen provides information to Supergirl about her lost home of Argo City in exchange for sparing his life.

Owlman, Ultraman, and Superwoman are briefly seen standing atop a building, with shadows obscuring most of their identifying marks, thus making it unclear which versions they are.

[23] In the ensuing storyline, Power Ring is killed and the members of the Justice League and the Crime Syndicate are forced to work together to stop the Omega Man.

Though his resurrection is short-lived, Luthor builds a machine that ultimately sends the Syndicate back to their own ravaged world and seemingly destroys the Omega Man.

[31] In "The New 52", with the changes of this new timeline, Crime Syndicate was introduced as the true antagonists of the "Villains Month" event, and the Forever Evil series.

[33] The New 52 line-up of the Crime Syndicate consists of Ultraman, Superwoman, Owlman, Johnny Quick, Power Ring, Deathstorm, Sea King (who does not survive the trip to Prime Earth) and two new members: Atomica, who had posed as the Atom while working as a mole for the Secret Society, and Grid, a sentient computer virus in a robot body made from Cyborg's old prosthetic parts.

[35] Batman, Lex Luthor and their team arrive at the fallen Watchtower and go in search of the kidnapped Dick Grayson (Nightwing) and the Crime Syndicate.

Batman, Luthor, Catwoman and Bizarro enter the room with Grayson and see he has been placed in a "Murder Machine" originally intended for Doomsday.

Following the reboot of the Multiverse at the end of Dark Nights: Death Metal as seen during the "Infinite Frontier", a new Earth 3 is created with a new Crime Syndicate with a different origin like Superwoman being Donna Troy, Owlman still being Thomas Wayne Jr. whose parents were killed by a mugger named Harvey Bullock under orders from Boss Gordon who considered them rival crime lords, Ultraman being Kal-El who was exploited by Jonathan and Martha Kent, John Stewart being a former beat cop before becoming Emerald Knight, and Johnny Chambers is a criminal who was raised by a father who trained dogs for dog fighting.

Lex Luthor starts to put together a resistance against them called the Legion of Justice that include New God Lonar, her horse Thunderer, Power Tower, Red Hood (Earth 3's Harley Quinn), Savanna, Sinestro, and Venus where their first mission results in the death of Johnny Quick before he can be recruited into the Crime Syndicate.

During the fight, Sinestro is killed by Emerald Knight, Atomica causes Ultragirl to die from a brain haemorrhage, and a badly-injured Lex Luthor is taken prisoner.

Following Death Metal, the new lineup features Ultraman, Owlman, Atomica, Donna Troy as Superwoman, Jonathan Chambers as Johnny Quick, and John Stewart as Emerald Knight / Power Ring.